Helping the heart to heal with stem cells
Article Abstract:
Research discussed concerns the use of bone marrow-derived angioblasts to encourage cardiac revascularization in the aftermath of a myocardial infarction or heart attack. Topics addressed include the physiological aspects of the myocardium and the utilization of stem cells to help the heart heal after a myocardial infarction.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
Article Abstract:
Research presented concerns the left-ventricle remodeling process after myocardial infarction, focusing on ways to inhibit myocardial remodeling and regenerate cardiac myocytes using mesenchymal stem cells derived from bone marrow. The therapeutic use of cytokine-mobilized angioblasts for revascularization of the heart muscle is addressed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
Article Abstract:
The role of proliferator-activated receptor-delta (PPAR-delta) in the heart in vivo is studied with the help of a cre-loxP-mediated cardiomyocyte-restricted gene targeting approach by crossing mice carrying a loxP-flanked allele of Ppard, the gene that encodes PPAR-delta with cardiomyocyte-restricted Cre-expressing (alpha-MyHc-Cre) mice. The findings indicate that PPAR-delta is essential for maintaining basal cardiac function, possibly through maintenance of basal myocardial fatty acid oxidation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Partial dissection of the zona pellucida of frozen-thawed human embryos may enhance blastocyst hatching, implantation, and pregnancy rates
- Abstracts: Histologic inflammation in the maternal and fetal compartments in a rabbit model of acute intra-amniotic infection
- Abstracts: No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status
- Abstracts: Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis. Profiling familial breast cancer
- Abstracts: Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads? A novel erythroid-specific marker of transmissible spongiform encephalopathies