Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission

Article Abstract:

Nitric oxide can cause relaxation of the corpus cavernosum, the erectile tissue of the penis. Strips of corpus cavernosum were obtained from 21 men who had received a penile prosthesis to treat impotence. Chemical methods were used to contract the smooth muscle of the corpus cavernosum, and the effect of electrical stimulation and nitric oxide on subsequent relaxation was measured. Electric stimulation caused a relaxation that was inhibited by compounds that inhibit the synthesis of nitric oxide by the muscle tissue. Nitric oxide applied directly also caused relaxation of the muscle. Nitric oxide may be involved in penile erection, and a defect in the biosynthesis or release of nitric oxide in the body may be responsible for some cases of impotence.

Research, Physiological aspects, Impotence, Nitric oxide, Smooth muscle

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After Bangkok - Expanding the global response to AIDS

Article Abstract:

The International AIDS Conference has become a forum to focus public attention on the many aspects of the epidemic. When the 16th International AIDS Conference begins in Toronto, by August 2006, the outcome of the WHO's 3-by-5 initiative will be known.

Conferences, meetings and seminars, Risk factors, AIDS (Disease), International relief organizations

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Tragedy and response -- the Rhode Island nightclub fire

Article Abstract:

A doctor at Kent County Hospital in Warwick, Rhode Island, describes the night of February 20, 2003, when 100 people died and more than 200 were injured in the Rhode Island nightclub fire.

Rhode Island, Personal narratives, Fires

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