Observations on the microenvironmental nature of cartilage degradation in rheumatoid arthritis
Article Abstract:
The deterioration that occurs within the knee joints of patients with rheumatoid arthritis appears to be coordinated locally. An analysis of the cell types and enzyme content was performed on various sections of 150 rheumatoid arthritic knee joint samples. Cell type patterns were irregular in patients with advanced disease indicating pockets of deteriorated tissue. The cells seen most frequently at sites of deterioration included those involved in the inflammation process such as fibroblasts, polymorphonuclear leukocytes, mast cells, and macrophages. Few samples showed evidence of enzyme production.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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Reduced cortical responses to noxious heat in patients with rheumatoid arthritis
Article Abstract:
Patients with rheumatoid arthritis (RA) appear to have developed an adaptive pain mechanism. Brain scans measuring blood flow patterns were used to evaluate pain responses as six patients with RA and six matched volunteers (control group) were subjected to two minutes of painful heat on the backs of their hands. Blood flow in the anterior cingulate, prefrontal, and cingulofrontal transition cortical areas of the brain were significantly lower among the patients with RA as compared to the control group. These patterns were different from published patterns for patients with atypical facial pain.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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Detection of oncostatin M in synovial fluid from patients with rheumatoid arthritis
Article Abstract:
A protein called oncostatin M (OSM) may play a role in the inflammatory process seen in patients with rheumatoid arthritis (RA). OSM levels were measured in joint fluid samples from 20 patients with RA and 10 patients with osteoarthritis (OA). There was a strong association between OSM levels and white blood count in these samples. OSM levels ranged from 2.36 picograms per milliliter (pg/mL) to 901.82 pg/mL in patients with RA. Samples from patients with OA contained no OSM.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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