Peripheral joint laxity increases in pregnancy but does not correlate with serum relaxin levels

Article Abstract:

Joint looseness experienced during pregnancy may not be related to the amount of relaxin in the blood, number of children, age, or exercise before pregnancy. Researchers measured the degree of joint looseness in the knees, elbows, and hands of 21 women before, during, and after pregnancy. Relaxin levels rose significantly with pregnancy, with a peak during the second trimester, but relaxin levels did not correspond to joint looseness. Joints seemed most loose in late pregnancy. Knee looseness declined from delivery to six weeks post partum, but joint looseness did not reach normal levels by six weeks post partum. There is no evidence that increased joint looseness in late pregnancy causes joint injury.

Joints, Joint instability

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Reproductive hormones and aminoterminal propeptide of type III procollagen in serum as early markers of pelvic pain during late pregnancy

Article Abstract:

Measuring blood levels of a hormone called relaxin and a protein called aminoterminal propeptide of type III procollagen may detect pregnant women who are at risk of back pain. The presence of aminoterminal propeptide of type III procollagen indicates that collagen is being synthesized in ligaments. This in turn means the ligaments are changing. In a study of 200 pregnant women, those with high blood levels of relaxin and low blood levels of aminoterminal propeptide of type III procollagen early in their pregnancy were more likely to develop back pain later in the pregnancy.

Forecasts and trends, Collagen

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Serum relaxin, symphyseal pain, and back pain during pregnancy

Article Abstract:

The hormone relaxin may be responsible for back and pelvic pain in pregnant women. Researchers measured blood levels of relaxin in 200 pregnant women at five different times throughout pregnancy and at 12 weeks after delivery. Women with elevated levels of relaxin experienced pelvic pain in late pregnancy by their own report and in response to a pain-provoking test. Relaxin is produced by the corpus luteum, and may be responsible for remodeling the connective tissue of the pelvis in pregnancy. Such remodeling may cause pain in the pelvic area.

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