Pharmacokinetic evaluation and short-term activity of stavudine, nevirapine, and nelfinavir therapy in HIV-1-infected adults
Article Abstract:
The study revealed that Nevirapine (NVP) administration did not affect the steady-state pharmacokinetic parameters of nelfinavir (NFV) or stavudine (d4T). Further results suggested that the combination of d4T, NVP and NFV induced rapid suppression of HIV-1 viral load and rises in CD4 cell count.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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A pharmacokinetic-pharmacodynamic model to optimize the phase lla development program of Maraviroc
Article Abstract:
A viral dynamics model is used to compare the effectiveness of in vivo viral inhibition of several doses of maraviroc. The use of model-based approach for selecting doses could accelerate drug development by replacing some arms or trials with simulations.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Baseline CD4+ cell count, not viral load, correlates with virologic suppression induced by potent antiretroviral therapy
Article Abstract:
An HIV patient's CD4 T cell count is a better predictor of the response to therapy than the amount of HIV in the blood. This was the conclusion of researchers who analyzed 30 studies of the treatment of HIV infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
User Contributions:
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