Preliminary experience with endoscopic laser surgery for severe twin-twin transfusion syndrome

Article Abstract:

Endoscopic laser coagulation of the placental blood vessels being shared by fetuses suffering from twin-twin transfusion syndrome appears to increase the fetuses' survival rate. In some monozygotic twin pregnancies, an imbalance of blood flow to the fetuses results in the sharing of a blood-source by both fetuses, often resulting in too little blood volume for one twin and too much blood volume in the other. Laser coagulation involves the use of a laser to clot the shared vessels. Previous approaches to treatment have yielded a survival rate for the fetuses of 32%. Forty-five women whose pregnancies were complicated by twin-twin transfusion syndrome, and whose fetuses were at risk as a result, underwent endoscopic laser surgery. The surgery was 100% successful at coagulating the identified blood vessels. Fifty-three percent of the fetuses survived to delivery.

Complications and side effects, Surgery, Fetofetal transfusion, Multiple birth

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Endoscopy laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome

Article Abstract:

A study was conducted on pregnant women with monochorionic twin pregnancies treated with serial amnioreduction or selective fetoscopic laser coagulation of the communicating vessels on the chorionic plate to compare the efficacy and safety of these two treatments. The results revealed that endoscopic laser coagulation is more effective for severe twin-to-twin transfusion syndrome diagnosed before 26 weeks of gestation.

Science & research, Care and treatment, Research, Comparative analysis, Fetoscopy, Amniocentesis, Pregnancy, Multiple, Multiple pregnancy

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HIV drug resistance

Article Abstract:

The mechanisms underlying the selection of drug-resistant HIV and the consequences of viral resistance are focused. Although viral resistance to new drugs can also develop, the lessons learnt during the process of development may prove helpful in devising new treatment strategies that minimize resistance to the new agents.

Influence, HIV antigens

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