Prenatal analysis of rhesus CcDEc blood groups by heteroduplex generator
Article Abstract:
Heteroduplex analysis may be a promising new molecular method for detecting Rh CcDEe blood incompatibilities between pregnant women and their fetuses. Researchers used a heteroduplex generator molecule to analyze prenatal fetal samples from 85 pregnant women and compared the results to standard analysis on cord blood after delivery. Sixty-four samples were tested for all Rh CcDEe antigens. Testing was inconclusive in one of these samples. In another five cases, the antigen could not be determined due to an unclear banding pattern. Heteroduplex analysis may be a less expensive, quicker, and safer method of Rh analysis.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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The sensitivity of allele-specific polymerase chain reaction can obviate concern of maternal contamination when fetal samples are genotyped for immune cytopenic disorders
Article Abstract:
Allele-specific polymerase chain reaction tests may accurately identify fetuses with a risk of immune disorders of the blood and may not be compromised by contamination with maternal blood. Researchers compared the sensitivity of variable-number tandem repeat analysis to that of allele-specific polymerase chain reaction in analyzing DNA from fetal blood in fetuses at risk for immune blood disorders. Allele-specific polymerase chain reaction was more sensitive than variable-number tandem repeat analysis, and could detect genetic information from the father even when maternal contamination exceeded 90% of the sample.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Prenatal screening for cystic fibrosis: an updated perspective
Article Abstract:
Prenatal screening for cystic fibrosis may identify over half of all affected fetuses among pregnancies with a high risk of cystic fibrosis. Couples where both the mother and father carry cystic fibrosis mutations may have a high risk of conceiving a fetus with cystic fibrosis. About one in 1000 couples has this condition, and their risk of having a baby affected with cystic fibrosis is one in four. Cystic fibrosis screening has comparable detection rates to screening for spina bifida and Down syndrome. Routine prenatal screening for cystic fibrosis may someday be a reality.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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