Prevention of diabetic embryopathy in offspring of diabetic rats with use of a cocktail of deficient substrates and an antioxidant

Article Abstract:

Dietary supplements of vitamin E, safflower oil, and myo-inositol may prevent fetal neural tube defects in diabetic pregnant rats. Researchers compared the fetal outcomes of diabetic and nondiabetic pregnant rats when some were given dietary supplements and others were given normal diets. Diabetic rats not receiving dietary supplements had a 23.7% rate of fetal neural tube defects compared with 4% in diabetic rats receiving a combination of vitamin E, safflower oil, and myo-inositol. Diabetics are known to have deficient amounts of these substances. Higher doses of the supplements provided greater protection from birth defects.

Abnormalities, Complications and side effects, Birth defects, Antioxidants, Antioxidants (Nutrients), Neural tube, Neural tube defects

---

Characterization of differential gene expression profiles in diabetic embryopathy using DNA microarray analysis

Article Abstract:

Gene expression profiles in the yolk sac tissues of rat embryos are characterized using DNA microarray analysis to determine the developmental genes and molecular pathways that are involved in diabetic embyropathy. Observations show significant alterations in expression of developmental and stress response genes in diabetic embryopathy, and demonstrate that the yolk sac cells express insulin during early development, and that hyperglycemia induces altered gene expression.

United States, Science & research, Research, Genetic aspects, Pregnant women, DNA microarrays

---

Dietary vitamin and lipid therapy rescues aberrant signaling and apoptosis and prevents hyperglycemia-induced diabetic embryopathy in rats

Article Abstract:

A study to investigate the molecular mechanism underlying diabetes-induced embryonic abnormalities and dietary interventions, activity of mitogen-activated protein kinases and actors associated with apoptotic pathways in maternal diabetic rat model were examined. The results revealed that mitogen-activated protein kinase were involved in diabetic embryopathy, and dietary supplementations could rescue the aberrant pathways and reduce embryonic malformation rate.

Risk factors, Protein kinases, Hyperglycemia

Similar abstracts:

• Abstracts: Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide. Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive
• Abstracts: Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
• Abstracts: Association of socioeconomic status with functional capacity, heart rate recovery and all-cause mortality. Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program
• Abstracts: Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
• Abstracts: Care pathways for pediatric continence. End-of-life decisions and respiratory disease

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.