Preventive effects of transdermal 17-beta-estradiol on osteoporotic changes after surgical menopause: a two-year placebo-controlled trial
Article Abstract:
Transdermal administration of 17-beta-estradiol appears to be a safe and effective form of estrogen replacement therapy. Estrogen replacement therapy in postmenopausal women prevents bone loss and lowers the risk of fractures. Transdermal administration of estradiol through a skin patch releases the hormone directly into the bloodstream. Of 98 women who had undergone surgical menopause following a total hysterectomy, 23 received 0.025 milligrams (mg) of 17-beta-estradiol daily through a skin patch, 23 received 0.05 mg, 20 received 0.1 mg and 32 received placebo, or inactive substance. Overall, bone density increased with higher doses of estradiol. Bone loss in the lumbar spine, which is the most common site of osteoporosis-related fractures in post-menopausal women, was reduced with the lowest dose but not prevented. Bone density of the lumbar spine remained stable in women who received 0.05 mg daily and significantly increased in women who received 0.1 mg per day. There were no serious side effects associated with the skin patch.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Percutaneous absorption of progesterone in postmenopausal women treated with transdermal estrogen
Article Abstract:
A cream containing progesterone appears to be properly absorbed and may be useful in treating menopausal symptoms. Six postmenopausal women applied the cream to their skin and also used an estrogen patch. Progesterone appeared in the women's blood and had no significant side effects.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Three-year follow-up of the use of transdermal 17beta-estradiol matrix patches for the prevention of bone loss in early postmenopausal women
Article Abstract:
An estradiol patch called Menorest appears to be effective in maintaining bone mass in postmenopausal women and increasing bone mass in women with low bone mass. This was the conclusion of a study of 325 postmenopausal women.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The effect of training on the provision of elective abortion: a survey of five residency programs. Safety of intra-amniotic digoxin administration before late second-trimester abortion by dilation and evacuation
- Abstracts: Effects of pulsed Nd:YAG laser energy on human teeth: a three-year follow-up study. Rationale and treatment aproach in minimally invasive dentistry
- Abstracts: Dental education summits: the challenges ahead. Dental insurance, managed care and traditional practice. Selling your practice at retirement: are there problems ahead?
- Abstracts: Breast cancer: an overview. The surgical management of breast cancer. Adjuvant treatment for breast cancer patients
- Abstracts: Primary and secondary prevention services in clinical practice: twenty years' experience in development, implementation, and evaluation