Reduced bone mass in daughters of women with osteoporosis

Article Abstract:

Osteoporosis, a degenerative bone disease, results from a reduction in the amount of bone mass, causing bones to fracture after minimal amounts of stress. The condition typically appears in postmenopausal women. In order to determine the role that genetics may play in osteoporosis, the bones of postmenopausal women with fractures caused by osteoporosis and the bones of their premenopausal daughters were compared to the bones of normal postmenopausal mothers and their premenopausal daughters. Compared to normal postmenopausal women, those with osteoporosis had lower bone mineral content in specific areas, namely the lower spine (lumbar spine), the thigh bone just below the hip joint (femoral neck), and the middle of the thigh bone (femoral midshaft) by 33, 24, and 15 percent, respectively. The daughters of women with osteoporosis also had lower bone mineral content in these spots (7 percent in the lumbar spine, 5 percent in the femoral neck, and 3 percent in the femoral midshaft) than the daughters of normal women. In addition, the daughters had reduced bone mass in the lumbar spine and perhaps in the femoral neck, putting them at an increased risk for bone fractures. The results also indicate that low peak bone mass, rather than excessive bone loss, may cause postmenopausal osteoporosis.

Analysis, Prevention, Genetic aspects, Osteoporosis, Fractures (Injuries), Fractures, Bone densitometry

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Bone quality- the material and structural basis of bone strength and fragility

Article Abstract:

The main purpose of bone modeling and remodeling throughout is to adapt the material composition and structure of bone to prevailing loads. The solution to the problem of bone fragility and structural failure requires a study of the qualities of bone and the cellular mechanisms maintaining the qualities from region to region in the body.

Health aspects

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Periosteal bone formation -- a neglected determinant of bone strength

Article Abstract:

A woman's bones may actually begin to grow again after menopause to compensate for the bone loss that occurs. This grow occurs in the periosteum, the outer layer of the bone, and compensates for bone loss in the inner layer. This can maintain the relative strength of the bone even as bone loss occurs.

Aging, Growth, Postmenopausal women, Bone development, Company growth

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