Redundancy of conventional articular response variables used in juvenile chronic arthritis clinical trials
Article Abstract:
A few well-chosen measurements of patients with juvenile chronic arthritis (JCA) seem to give a simpler but equally accurate assessment of disease progression as compared to the redundancy occurring in current diagnostic and monitoring practices. Researchers statistically analyzed four separate studies of 508 patients with JCA that compared the effects of one of four treatments (oral gold, D-penicillamine and hydroxychloroquine, methotrexate, or immunoglobulin) with placebo. The study researchers recorded 11 characteristics on each of 71 joints. Changes in the number of joints involved and changes in disease severity at the respective joint were statistically identical. There was a strong association between the reported changes in overall disease severity assessments and most of the other measurements made. Morning stiffness evaluations did not statistically correspond to any of the other measurements.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Do gold rings protect against articular erosion in rheumatoid arthritis?
Article Abstract:
It appears that patients with rheumatoid arthritis (RA) who wear gold rings may have delayed disease progression in the ringed and adjacent joints. RA disease progression as measured by Larsen scores on x-ray was compared in the left ring finger joints of 30 long-term ring wearers and 25 long-term non-ring wearers. Larsen scores were lower in the left ring finger joint of ring wearers than both their own right ring finger joint and the non-ring wearers' left ring finger joint. Larsen scores were also lower in the ring wearers' left middle finger joint.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Pregnancy and early onset pauciarticular juvenile arthritis
Article Abstract:
The authors examine the relationship between pregnancy and early onset pauciarticular juvenile arthritis (EOP-JCA) in a Polish population. they found that the pregnancy was successful, but after delivery, there was a flare-up of EOP-JCA particularly among women who were breast feeding.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis. Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison
- Abstracts: Use of monoclonal antibodies to detect disease associated HLA-DRB1 alleles and the shared epitope in rheumatoid arthritis
- Abstracts: Urine concentration and enuresis in healthy preschool children. part 2 Hyponatremic seizure in a child using desmopressin for nocturnal enuresis
- Abstracts: California pediatricians' knowledge of and response to recommendations for universal infant hepatitis B immunization
- Abstracts: Potential effects of managed care on specialty practice at a university medical center. Trends in health care coverage and financing and their implications for policy