Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
Article Abstract:
Research on laboratory mice indicates that acyl CoA:cholesterol acyltransferase (ACAT2) deficiency provides a significant level of resistance to cholesterol-induced gallstones and hypercholesterolemia. Inhibition of ACAT2 may therefore be a successful strategy for treating or preventing diseases related to cholesterol-rich diets.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Turning WAT intp BAT gets rid of fat
Article Abstract:
Research has been conducted on the knockout mouse models of leanness and obesity resistance. The generation of the new lean mouse model via inactivating the gene for an inhibitor of mRNA translation has been carried out and discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
Article Abstract:
Research has been conducted on the nuclear-encoded mRNA containing a 5' cap structure recognized by the eukaryotic translation initiation factor 4E (elF4E) subunit of the elF4E complex. The biological function of elF4E has been investigated via the disruption of its gene in the mouse.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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