The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of antiogenic growth factors
Article Abstract:
Research has been conducted on the prototypical morphogen Sonic hedgehog which regulates epithelial and mesenchymal interactions during embryonic development. Results indicate that the hedgehog-signaling pathway is present in the cardiovascular tissues of the adults and can be activated in vivo.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy
Article Abstract:
Researchers were able to reverse the symptoms of hindlimb ischemia in rabbits by intramuscular injections of DNA coding for vascular endothelial growth factor. This growth factor is involved in angiogenesis, which could create collateral blood vessels in patients with ischemia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling
Article Abstract:
Sonic hedgehog (Shh) is a crucial regulator of organ development during embryogenesis. The intramyocardial gene transfer of naked DNA is investigated to see whether encoding human Shh could promote a favorable effect on recovery from acute and chronic myocardial ischemia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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