Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals
Article Abstract:
The mitochondrial DNA (mtDNA) levels in matched samples of peripheral blood mononuclear cells (PBMCs) and subcutaneous fat from a large Australian cohort were studied to examine treatment, clinical, and demographic association with mtDNA depletion. The results confirm a tissue- and drug-specific association between nucleoside reverse transcriptase inhibitor (NRTI) exposure and mtDNA levels and there was no effect of the duration of therapy, suggesting that mtDNA depletion occurs rapidly when NRTIs are commenced.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Adverse effects of antiretroviral drugs on HIV-1-infected and -uninfected human monocyte-derived macrophages
Article Abstract:
A study was conducted to investigate the effects of nucleoside reverse transcriptase inhibitors (NRTIs) on the viability and function of HIV-1-infected and -uninfected human monocyte-derived macrophages (MDMs) associated with reduced phagocytic capacity of macrophages, a crucial function in host surveillance and immunity. Results have important implications for use of these antiretroviral drugs in immunocomprised individuals.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Increased adipocyte apoptosis in lipoatrophy improves within 48 weeks of switching patient therapy from stavudine to abacavir or zidovudine
Article Abstract:
The degree and reversibility of adipocyte apoptosis in patients with lipoatrophy before and 48 weeks after substituting abacavir or zidovudine for stavudine is assessed. It is concluded that increased apoptosis is present in fat samples from patients with lipoatrophy treated with stavudine.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2005
User Contributions:
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