Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: clinical and endometrial responses

Article Abstract:

An estrogen patch in combination with an intrauterine device (IUD) that slowly released progestin proved as effective and safe as oral estrogen and progestin for menopausal women. Progestin prevents the abnormal growth of the uterine lining that occurs with estrogen alone. Forty menopausal women were randomly assigned to one or the other therapies. The IUD was sufficiently large that insertion was only attempted in women who had previously born children and who had been pretreated for one month with estrogen. Even so, the device could not be inserted in one patient and four others had it removed because of continuous pain and bleeding. Two oral medication patients withdrew because of spotting and one because of dry eyes and headache. Women with the IUD were more likely to spot within the first three months, but this subsided. Transvaginal ultrasound established that neither regimen caused abnormal growth of the uterine lining. Menopausal symptoms were relieved equally well in both groups.

Evaluation, Drug therapy, Dosage and administration, Progestational hormones, Intrauterine devices, Estradiol, Contraceptive drugs, Intrauterine contraceptives, Medicated

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Impact of climacteric on well-being: a survey based on 5213 women 39 to 60 years old

Article Abstract:

Overall well-being in women of menopausal age appears to be associated more with the severity of vasomotor complaints than stage of menopause or age. Vasomotor complaints include sweating and flushes and are considered typical of menopause. Atypical complaints of menopause include dizziness, depression and muscle or joint pain. In a survey of 5,213 women aged 39 to 60, 41.1% of regularly menstruating women reported vasomotor complaints. Vasomotor complaints were reported by 85% of women at menopause and by 57% whose last menstrual period was more than 10 years prior to the survey. Atypical complaints, especially tenseness and tiredness, increased significantly with the severity of vasomotor complaints. Menstruating women reported atypical complaints more often than non-menstruating women. Once women had stopped menstruating, age had almost no effect on the incidence of atypical complaints.

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Hysterectomized women with ovarian conservation report more severe climacteric complaints than do normal climacteric women of similar age

Article Abstract:

Women who have undergone hysterectomy with ovarian conservation appear to experience more problems with flushes and vaginal dryness during menopause than women who have not had hysterectomies. Complaints associated with menopause were compared between 986 women who had had a hysterectomy but still had one or both or their ovaries and 5,636 women of the same age who had not undergone hysterectomy. Overall, hysterectomized women reported moderate to severe complaints 1.2 to 3.1 times more often. They reported moderate to severe sweating and flushing 1.3 to 1.9 times more often and moderate to severe vaginal dryness 1.3 to 4 times more often. They were also 1.3 to 2.6 times more likely to report complaints not normally associated with menopause like burning during urination and tiredness. The greatest differences between the two groups occurred among women aged 39 to 41.

Complications and side effects, Hysterectomy

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