VX-680, a potent and selective small-molecule inhibitor of the Aurora-kinases, suppresses tumor growth in vivo
Article Abstract:
The discovery of a highly potent and selective small-molecule inhibitor of Aurora kinases, VX-680 that is essential for the regulation of chromosome segregation and cytokinesis during mitosis is reported. Data indicates that Aurora kinase inhibitor provides a new approach for the treatment of multiple human malignancies.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: Mapping tumor invasion of the prostrate capsule
Article Abstract:
A set of novel 'tissue print' and 'print phoresis' technologies to facilitate tissue and tumor-marker profiling under these circumstances are developed. These technologies are used to identify and characterize markers of tumor invasion of the prostrate capsule that may result in tumor at the surgical margins.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six - 1 as key metastatic regulators
Article Abstract:
Ezrin, a cytoskeletal organizer and Six - 1, a developmental homeoprotein are identified as regulators of metastasis in rhabdomyosarcoma (RMS). They further provide new mechanistic and therapeutic insights for the pediatric cancer.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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