Pleasure into pain: The consequences of long-term opioid use

Article Abstract:

Opioids such as heroin produce analgesia, and people with a history of opioid self-administration are hypersensitive to certain kinds of pain during the time they are under the influence of the analgesic drug. This hyperalgesia is evident in people with a history of heroin use and is not modified by methadone or buprenorphine treatment but is reduced by long-term abstinence from opioids.

Narcotic Analgesic Preparations, Methadone (Unit Dose), Evaluation, Causes of, Opioids, Analgesia, Methadone hydrochloride, Methadone

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Context of relapse for substance-dependent adults with and without comorbid psychiatric disorders

Article Abstract:

The context of initial post-treatment substance use episodes, and one-year treatment outcomes is examined among adult substance abusers in relation to Axis I psychiatric diagnoses. Results highlight important differences in the process of resuming substance use for substance abusers with concomitant psychiatric disorders compared to adults with substance use disorders.

Psychotherapeutic Preparations, Diseases, Dosage and administration, Psychotropic drugs, Recurrence (Disease), Psychoses, Psychotic disorders

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Psychiatric severity and mortality in substance abusers: A 15-year follow-up of drug users

Article Abstract:

Mortality rate in substance abusers who went through detoxification is examined through a 15-year follow-up study.

United States, Mortality, Patient outcomes, Detoxification (Substance abuse treatment), Substance abusers

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