A "faux" 3'-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay
Article Abstract:
The nonsense-mediated messenger RNA is triggered by premature translation termination, but the features distinguishing premature from normal termination are unknown. A decay inducing factor model with factors bound to mRNAs during early processing events are routinely removed by elongating ribosomes but remain associated with mRNAs when termination is premature triggering rapid turnover.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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An elF4Alll-containing complex required for mRNA localization and nonsense-mediated mRNA decay
Article Abstract:
The elF4AIII and Barentsz are identified as components of a conserved protein complex that is essential for mRNA localization in flies and nonsense-mediated mRNA decay (NMD) in mammals. This localization requires several transacting factors, including Barentsz and the Mago-Y14 heterodimer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila
Article Abstract:
The degradation of premature termination codons (PTC)-containing messages in Drosophila is initiated by endonucleolytic cleavage in the vicinity of the nonsense codon. The endonucleolytic cleavage is the predominantly nonsense-mediated mRNA decay (NMD) pathway in Drosophila cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
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