A model for p53-induced apoptosis
Article Abstract:
Researchers investigated genetic transcription caused by the p53 gene. There is much ongoing research into the p53 gene due to its inactivation in many human cancers. The researchers studied 7,202 transcripts and found that 14 showed a significant increase in cells with p53 expression compared to those in the control group. These were largely genes involved in oxidation. This finding stimulated further experiments suggesting that p53 causes cell death by inducing transcription in these redox-related genes to form a reactive oxygen species and the oxidative breakdown of mitochondrial components.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Life (and death) in a malignant tumour
Article Abstract:
The investigation of the p53 genes provides additional data for understanding tumor evolution. Studies of p53 genes in the past connected cancer genetics with other vital processes. T.G. Graeber and colleagues show that cells without intact p53 are resistant to hypoxia-induced death. Genetic, biochemical, and physiological research on p53 reveals certain properties. Researchers await understanding of the biochemical pathways that link specific genetic alterations to these processes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Inactivation of hCDC4 can cause chromosomal instability
Article Abstract:
Aneuploidy, an abnormal chromosome number, is recognized as a feature of human cancer. The identification of mutations in hCDC4 or Archipelago in both human colorectal cancers and their precursor lesions are reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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