AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Article Abstract:
The potential of AMP-activated protein kinase(AMPK), that acts as a fuel gauge to monitor cellular energy in the hypothalamus, in the regulation of food intake, was studied. The results indicate that the AMOPK activity is inhibited, either in the arcade and paraventricular hypothalamus or in the multiple hypothalamic regions by different factors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Identification of nesfatin-1 as a satiety molecule in the hypothalamus
Article Abstract:
A study was conducted to show that nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in the appetite-control hypothalamic nuclei in rats. Nesfatin-1 was identified as a satiety molecule that is associated with melanocortin signaling in the hypothalamus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1 alpha transcription coactivator
Article Abstract:
The article describes a process wherein insulin, through the protein kinase, holds on to the lipid catabolism in the liver thereby stopping the growth of type 2 diabetes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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