Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
Article Abstract:
Phenotypes linked to a single point mutation in Notch1, Val1,744-Gly, are shown to resemble null Notch1 phenotype.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Article Abstract:
Two models are introduced to describe alternative mechanisms of notch protein interaction. The first supposes that the CBF1, Su(H), Lag-1 (Super 1-4), or CLS, interacts directly with the Notch protein to produce an intracellular signal. The second assumes that the Notch interacts indirectly with CSL via the Notch intracellular domain NICD.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
Article Abstract:
Efficient processing of the receptor protein Notch-1 to produce Notch intracellular domain (NICD) needs presenilin-1 (PS1) and is inhibited by gamma-secretase inhibitors. PS1 deficiency does not have an impact on the expression of endogenous Notch-1, its maturation by a furin-like enzyme and the translocation of NICD to the nucleus. The role of PS1 in Notch/beta-amyloid precursor protein (APP) processing could be that of a facilitator, directly exposing APP and Notch-1 to the gamma-secretase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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