A progeroid syndrome in mice is caused by defects in A-type lamins
Article Abstract:
Research characterizes mice carrying an autosomal recessive mutation in the A-type lamins encoding gene. Homozygous mice exhibit defects like reduction in growth rate and death in 4 weeks, pathologies of bone, muscle, and skin consistent with the Hutchinson-Gilford progeria syndrome. Data indicate that the gene mutationalso causes nuclear morphology defects and lifespan reduction in fibroblasts leading to premature cell death.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Mice and mitochondria
Article Abstract:
Mitochondria are little pockets of energy within cells, carrying out the important task of converting food into usable energy forms, and they have their own genomes. The mutant mice showed symptoms consistent with accelerated aging such as premature weight loss, hair loss, and reduction in fertility, curvature of the spine and a shortened lifespan.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Lessons from human progeroid syndromes
Article Abstract:
Issues surrounding the effect of human gene mutations on the ageing process are discussed. Segmental progeroid syndromes including Werner syndrome and Hutchinson-Gilford syndrome are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
- Abstracts: The effect of reward band value on mid-continent mallard band reporting rates. Modeling spatial variation in waterfowl band-recovery data
- Abstracts: The business of brainwashing: corporations in the classroom. Consumerism and Animals
- Abstracts: Arginine vasotocin increases calling-site acquisition by nonresident male grey treefrogs. The neuropeptide arginine vasotocin alters male call characteristics involved in social interactions in the grey treefrog, Hyla versicolor
- Abstracts: Goldin wants more NASA biologists as Gore is briefed on space plans. Biologists challenge sequencers on parasite genome publication