Altered Hox expression and segmental identity in Mll-mutant mice
Article Abstract:
The Mll gene regulates Hox gene expression, exhibits haplo-insufficiency and is necessary for segment identity in mammals. Researchers studied the involvement of Mll in pattern development in mutant mice. Mll -/- mice died as embryos. Mll +/- mice were deformed and growth retarded. They also had segment identity abnormalities aw well as caudal shifts. Mll-mutant mice have many features in common with trx mutants.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Bax suppresses tumorigenesis and stimulates apoptosis in vivo
Article Abstract:
The role of the death-promoting gene Bax in a transgenic mouse brain tumor was examined using a model in which protein p53-mediated apoptosis attenuates tumor growth. It was found out that inactivation of p53 accelerates tumor growth due to a reduction in apoptosis. The results suggest that Bax, which functions as a tumor suppressor, may have an important role in the p53-mediated apoptotic response.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Article Abstract:
Mice conditional for Mcl- 1 display a profound reduction in B and T lymphocytes when MCL-1 is removed. Deletion of Mcl- 1 during early lymphocyte differentiation increased apoptosis and arrested the development at pro-B-cell and double- negative T- cell stages.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Shotgun sequence assembly and recent segmental duplications within the human genome. The DNA sequence of human chromosome 7
- Abstracts: Evolutionary change from induced to constitutive expression of an indirect plant resistance. A newly discovered species of living baleen whale
- Abstracts: The Mesp 2 transcription factor establishes segmental borders by suppressing Notch activity
- Abstracts: Aggregation and vesiculation of membrane proteins by curvature-mediated interactions. Evolutionary conservation of biogenesis of beta-barrel membrane proteins
- Abstracts: What's best on the banks? Decoupling of erosion and precipitation in the Himalayas