Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
Article Abstract:
Immunohistochemistry and in situ hybridization were performed to investigate the role of Hoxb-1 gene in the organization of motor neurons in mice. Hoxb-1 has been known to be expressed in rhombomere 4 (r4) and the results of the experiment confirmed that its absence causes changes in the identity of r4. The results further showed that Hoxb-1 plays the role of maintaining rhombomere identity by controlling the migratory properties of motor neurons in the hindbrain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC
Article Abstract:
A study of mice with mutated cells found that those that were homozygous for the xerodema pigmentosa Group C mutant allele had a higher incidence of tumor growth than a control population or mice heterozygous for the mutant allele. The mice were mutated using embryonic stem cell technology.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Targeting of sheep
Article Abstract:
Issues are presented concerning the use of transgenic technology in the breeding of sheep. The benefits and the limitations of this genetics procedure are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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- Abstracts: Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Defects in enteric innervation and kidney development in mice lacking GDNF
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- Abstracts: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone