B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
Article Abstract:
In vivo Oct binding factor (OBF)-1 is not necessary for initial transcription of immunoglobulin genes or for B cell development. Rather, it is crucial for the response of B cells to antigens and is required for the formation of germinal centers. This is gleaned from an investigation of the in vivo role of OBF-1 using gene targeting in embryonic stem cells to generate mice lacking the coactivator OBF-1. The mice are born normally, are fertile and appear healthy. Unexpectedly, no effect was noted in the rearrangement and transcription of immunoglobulin genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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In vivo imaging of germinal centres reveals a dynamic open structure
Article Abstract:
Two-photon laser-scanning microscopy is used in the direct visualization of B cells in lymph node germinal centers in mice. The results have shown that high-affinity antigen-specific B cells can be recruited to an ongoing germinal-centre reaction and the open structure of germinal centres have enhanced competition, ensuring that rare high-affinity B cells can participate in antibody responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Chromatin dynamics and the preservation of genetic information
Article Abstract:
The article describes the importance of DNA repair and the effects of chromatin on this DNA repair which helps preserve genes and the genetic knowledge in the DNA.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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