Baf60c is essential for function of BaF chromatin remodeling complexes in heart development
Article Abstract:
The 'Smarcd3' encoding Baf60c, a subunit of the BaF complexes is expressed specifically in the heart and somites in the early mouse embryo. The Smarcd3 silencing by RNA interference in mouse embryos derived from embryonic stem cells causes defects in heart morphogenesis that reflect impaired expansion of the anterior/secondary heart field and also results in abnormal cardiac and skeletal muscle differentiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Endothelial cells and VEGF in vascular development
Article Abstract:
Fish, chicks and mice that have dissected early patterning of the vascular endothelial system with particular reference to the role of endothelial cells and VEGF are studied. New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stemcell niches highlight possible side effects of the anti-angiogenic therapy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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A balancing act
Article Abstract:
Mutations in model organisms help assigning functions to genes. Chromosome engineering in mice makes it easier to pinpoint the location of random induced mutations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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