Essential functions of synapsins I and II in synaptic vesicle regulation
Article Abstract:
At the conditions of accelerated vesicle traffic, the synapsins I and II adjust the transfer of fusion-competent synaptic vesicles at the active site. The synaptic vesicles are destabilized in the absence of the regulatory function. Stimulation of mice bred without either I or II shows that the two synapsins are redundant and only when mice are bred without either does stimulation result in seizures. However, the seizures do not otherwise impair the mice nor is their life expectancy lower than mice with both synapsins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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BCI10 activates the NF-kB pathway through ubiquitination of NEMO
Article Abstract:
A biochemical purification method is used to identify components of BCI 10 signalling complex. The adaptor protein BCI 10 promotes activation of NF-kB transcription factors through paracaspaseand UBCI13-dependent ubiquitination of NEMO.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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