CD38 is critical for social behavior by regulating oxytocin secretion
Article Abstract:
Mice with CD38 gene disruption ([CD38.sup.-/-] are used to show that CD38-dependent cyclic ADP-ribose (cADPR)- and nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive intracellular [Ca.sup.2+] mobilization has a main role in oxytocin (OT) release from soma and axon terminals of hypothalamic neurons, with profound consequential changes in social behaviors. The results have disclosed that CD38 has a major role in neuropeptide release, thereby regulating maternal and social behaviors and might be an element in neurodevelopmental disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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A sweet synthesis
Article Abstract:
A strategy for assembling glycopeptides using a process known as peptide ligation where one peptide is attached to another that incorporates modified sugar is presented. The emergence of constructing pure peptides and proteins with sugar installed at preselected sites has many implications and due to their ability to fine-tune biological properties of therapeutic proteins by modifying their attached sugar could lead to exciting advances in drug discovery.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Channels for pathfindings
Article Abstract:
Transient receptor potential (TRP) proteins that form ion channels allow adult sensory organs to respond to temperature, mechanical stress or taste. Scientists have found the TRP channels at the tip of embryonic nerves, which are responsible for the growth of the nerves towards or away from the guidance molecule.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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