Can less be more for p53?

Article Abstract:

The p53 tumor-suppressor protein is believed to be important as it mediate the cell's response to particular type of injury, associated with a predisposition to cancer, sending signals from both the DNA-damage response pathway and the oncogenic (tumour- promoting) stress pathway. The researchers however feel that the deficiency of p53 is not always harmful and reducing this protein might lessen the toxic side effects of chemotherapy and radiotherapy.

Health aspects, Complications and side effects, DNA damage, Chemotherapy, Tumor proteins, Tumour proteins

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Improved mouse models

Article Abstract:

A new generation of genetically modified mice may provide an effective model of sporadic cancer. Mice which have been genetically engineered to be prone to tumours do not tend to be good models of sporadic tumours. The new mutant mice offer a more convincing model of sporadic lung cancers among humans.

Models, Usage, Innovations, Tumors, Genetically modified mice, Animal models in research, Animal research models

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Two in one

Article Abstract:

The MYC function in Burkitt's lymphoma, a malignancy of immune cells called B cells, which normally produce immunoglobulins in response to an immune attack is examined. It is found that the ARF-p53 pathway, a known target of MYC, was induced equally by wild-type and mutant MYC.

Cell death, Burkitt's lymphoma, Burkitt lymphoma

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