Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II
Article Abstract:
It has been possible to identify a chromatin-accessibility complex (CHRAC) which uses energy to boost the general accessibility of DNA in chromatin. CHRAC has been found to use ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. It is suggested that the nucleosome-stimulated ATPase activity in CHRAC is due to ISWI, which is found in both CHRAC and NURF, another nucleosome-remodelling complex that facilitates the binding of transcription factors to chromatin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A finger on the mark
Article Abstract:
The packaging, organization and indexing of genomes in the nucleus are achieved through their association with a large number of proteins to form a complex structure called chromatin. Chromatin is found to be marked chemically by a methylation mark as a method of indexing the underlying genes and a novel principle by which an H3K4 (lysome 4 of histone H3) methyl mark is recognized and translated into gene-expression patterns is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Regulation of cell cycle progression and gene expression by H2A deubiquitination
Article Abstract:
The identification and functional characterization of the major deubiquitinase for histone H2A, Ubp-M, which plays an important role in cell cycle progression and gene expression, are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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