The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
Article Abstract:
The transcriptional repressor jumonji C (JmjC)-domain-containing histone demethylase 3A (JHDM3A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36). Overexpression of JHDM3A abrogates recruitment of heterochromatin protein 1 (HP1) to heterochromatin, indicating a role for JHDM3A in antagonizing methylated H3K9 nucleated events, also indicating its function in euchromatin to remove histone methylation marks associated with active transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response
Article Abstract:
A demonstration that lysine 56 (K56) acetylation is an abundant modification of newly synthesized histone H3 molecules that are incorporated into chromosomes during S phase is presented. Defects in the acetylation of K56 in histone H3 result in sensitivity to genotoxic agents that cause DNA strand breaks during replication.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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p53 is regulated by the lysine demethylase LSD1
Article Abstract:
The article describes that in human cells the histone lysine-specific demethylase LSD1 interacts with p53 to repress p53-mediated transcriptional activation to inhibit the role of p53 in promoting apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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