Dispersion of neural progenitors within the germinal zones of the forebrain
Article Abstract:
The movement of labelled stem cells in the ventricular zones of the dorsal and basal regions of the E15 murine telencephalon was observed over an 8-24-hour period. The aim was to investigate the mechanism for the establishment of regional diversity in the forebrain during early neurogenesis. The results showed that stem cell movement was extensive in the plane of the cortical ventricular zone, but was restricted at the border between the cortical ventricular zone and the basal telencephalic ventricular zone. This suggests that restriction of cell movements may be one mechanism for establishing regional diversity in the developing forebrain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS
Article Abstract:
New research has emphasized the role of the roof plate in normal central nervous system development. It was found that the phenotype of the spontaneous neurological mutant mouse dreher is caused by a failure of the roof plate to develop. This in turn has an impact on dorsalization of the neural tube. It is suggested that, as in more caudal regions of the embryo, the roof plate could be vital for dorsal patterning within the cerebellum. It may be possible to extend the general model of dorsal fate specification to rostral areas of the developing nervous system.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Article Abstract:
A large-scale screen to create an atlas of Central Nervous System (CNS) gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosomes (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways are described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Moose dispersal and its role in the maintenance of harvested populations. Management of roadside salt pools to reduce moose-vehicle collisions
- Abstracts: Discovery of an X-ray afterglow associated with the gamma-ray burst of 28 February 1997
- Abstracts: Interaction of polyadenylate-binding protein with the elF4G homologue PAIP enhances translation. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons
- Abstracts: A specific neural substrate for perceiving facial expressions of disgust. Effects of sexual dimorphism on facial attractiveness
- Abstracts: Effect of auxiliary males on territory ownership in the oribi and the attributes of multimale groups. The maintenance of borders between male oribi