Dynamics of stripe formation
Article Abstract:
The developmental mechanisms causes stripes in some creatures such as zebrafish and Drosophila are linked to the pair-rule genes though zebrafish have a different mechanism governing the spread of stripes when compared to Drosophila. New zebrafish stripes can develop from intercalation or splitting in existing stripes in a zipper-like pattern, both of which increase the area covered by the stripes which is unlike the rigid coordinate system in Drosophila. Another dynamic stripe regulation involves stripes in Tribolium insects and some Drosophila where the space between primary stripes is too large and so secondary stripes develop.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Colour-coded switches
Article Abstract:
The classical mouse coat-color genes Agouti and Extension are known to affect the synthesis of products that are involved in a receptor-ligand complex. The latest studies show that mutations at the agouti locus affect an antagonist which prevents the ligand, alpha-melanocyte-stimulating hormone (alpha-MSH), from binding to the alpha-MSH-specific receptor, which is a product of the Extension locus. Mutations leading to normal agouti, black, yellow and black and tan phenotypes are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Requirement for Lim1 in head-organizer function
Article Abstract:
Lim1, a homeobox gene, has a major role in head formation during mouse embryogenesis. The deletion of the Lim1 gene in embryonic stem cells results in the development of trunk and tail areas devoid of anterior head structures. Some mutant embryos exhibit a partial development of anterior secondary axis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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