Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo
Article Abstract:
The nerve terminal protein synaptosomal protein-25 (SNAP-25) plays a key role in axonal growth. The protein is expressed in axonal growth cones during late stages of elongation and suppression of the protein prevents neurite elongation by rat cortical neurons and PC-12 cells in vitro. SNAP-25 inhibition also prevents elongation of the developing chick retina in vivo. These findings suggest that high levels of SNAP-25 expression may contribute to nerve terminal plasticity in the adult brain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Antisense oligonucleotides to NDMA-R1 receptor channel protect cortical neurons from excitoxicity and reduce focal ischaemic infarctions
Article Abstract:
The effect of antisense oligodeoxynucleotide (ODN) administration on N-methyl-D-aspartate-R1 (NMDA-R1) was examined in vivo and in vitro. Results revealed that NMDA receptor-mediated Ca2+ influx was inhibited in neuron-enriched cultures with antisense ODN treatment, which also prevented NMDA-elicited neurotoxicity. In live rats, antisense ODN treatment also reduced focal ischaemic infarctions caused by middle cerebral artery occlusion by selective suppression of NMDA-R1 protein translation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
Article Abstract:
The brain-derived neurotrophic factor (BDNF) is essential for the extension and remodelling of the axonal branches and spikes in the central nervous system. Optic axon branching in Xenopus laevis tadpoles in vivo decreases at lower levels of BDNF in the optic tectum. Specific neutralizing antibodies of BDNF deplete the axon elaboration. The in vivo retinal ganglion cell response is related to BDNF. BDNF plays an important role in the interaction between the axon terminals and their targets.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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