EphB receptor activity suppresses colorectal cancer progression
Article Abstract:
A demonstration that although Wnt signaling remains constitutively active, most human colorectal cancers lose expression of EphB at the adenoma-carcinoma transition is presented. EphB guidance receptors are Tcf4 target genes that control intestinal epithelial architecture through repulsive interactions with Ephrin-B ligands.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Identification of stem cells in small intestine and colon by marker gene Lgr5
Article Abstract:
The lineage-tracing experiments performed in adult mice by using inducible Cre knock-in allele and the Rosa26-lacZ reporter strain are reported. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), a marker gene identified stem cells expressed in the small intestine and colon cancer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
The Wntlbeta-catenin pathway regulates cardiac valve formation
Article Abstract:
Adenomatous polyposis coli (Apc) constitutively activates the Wnt/beta-catenin. Examples of embryos of mice with truncated Apc, do not complete gastrulation. The effect of truncated Apc, on zebrafish development is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A provirus put to work. Proviruses pose potential problems. Retrovirus restriction revealed
- Abstracts: Transient cross-reactive immune responses can orchestrate antigenic variation in malaria. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
- Abstracts: A tuxedo for iodine atoms. Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands
- Abstracts: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. part 2 Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
- Abstracts: Asymmetric and symmetric stem-cell divisions in development and cancer. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes