Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
Article Abstract:
The T cells from pancreatic draining lymph nodes, the site of islet-cell-specific self-antigen presentation, are examined. The results identify insulin-reactive, clonally expanded T cells from the site of autoinflammatory drainage in long-term type 1 diabetics, indicating that insulin may indeed be the target antigen causing autoimmune diabetes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Article Abstract:
The presence and importance of macrophages on the floor of subcapsular sinus (SCS) and in the medulla of lymph nodes in clearing lymph-borne viruses are demonstrated. These macrophages are found to be extremely useful in initiating humoral immune responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Article Abstract:
The phenotype of injected dendritic cells (DCs) that migrated to draining lymph nodes (LNs) is examined. Primary T-cell responses in LNs require contactdependent information exchange between T cells and DCs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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