Functional receptor for GDNF encoded by the c-ret proto-oncogene
Article Abstract:
Analysis of biochemical responses to glial-cell-line-derived neurotrophic factor (GDNF) indicates that the Ret receptor tyrosine kinase acts as a signal-transducing receptor for GDNF. This functional receptor is a product of the c-ret proto-oncogene and may mediate its neurotrophic effects on motor and dopaminergic neurons. GDNF binds to, and induces tyrosine phosphorylation of the Ret receptor. The GDNF binding components are identified through chemical crosslinking of 125I-GDNF to MN1 monolayers. Observations are made on serum-deprived motor-neuron monolayers (MN1) of embryonic mouse.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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GDNF signalling through the Ret receptor tyrosine kinase
Article Abstract:
Xenopus embryo bioassays reveal Ret to be a functional receptor for glial-cell-line-derived neurotrophic factor (GDNF) with signalling occurring through the Ret receptor tyrosine kinase (RTK). Explant culture studies of wild-type and Ret-deficient mouse embryos show the important influence of c-ret function for GDNF signalling in the peripheral nervous system. GDNF is a distant member of the transforming growth factor-beta superfamily and has a profound influence on kidney organogenesis. Bioassays are conducted using immunoprecipitation and western blotting.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
Article Abstract:
The study suggests that conserved dopamine neurotrophic factor (CDNF), a new neurotrophic factor for dopaminergic neurons could be most beneficial for the treatment of Parkinson's disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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