GABA regulates synaptic integration of newly generated neurons in the adult brain

Article Abstract:

A study show that newborn granule cells in the dentate gyrus of the adult hippocampus are activated tonically by ambient GABA (gamma-aminobutyric acid) before being sequentially innervated by GABA- and glutamate-mediated synaptic inputs. The results identify an essential role for GABA in the synaptic integration of newly generated neurons in adult brains and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.

Health aspects, Infants (Newborn), Newborn infants, Brain cells

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A topographic map of recruitment in spinal cord

Article Abstract:

Electrophysiology and in vivo imaging is used in larval zebrafish (Danio rerio) to disclose a systematic relationship between the location of a spinal neuron and the minimal swimming frequency at which the neuron is active. The results have shown an unexpected pattern of organization within zebrafish spinal cord that underlies the production of movements of varying speeds.

United States, Spinal cord, Animal locomotion

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