Generation of neuronal variability and complexity
Article Abstract:
The molecular mechanisms that contribute to neuronal diversity are reviewed, where diversity exists between individual cells within a neuronal subtype and neurons within a similar morphology can differ in important molecular details. The production of neuronal diversity from a relatively homogenous population of neural stem cells in culture is of great importance for the treatment of several neurological diseases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
Article Abstract:
An engineered human LINE-1 (also known as L1), element that can retrotranspose in neuronal precursors derived from rat hippocampus neural stem cells is shown. The resulting retrotranspositon events can alter the expression of neuronal genes, which in turn can influence neuronal cell fate in vitro, and retrotransposition of a human L1 in transgenic mice results in neuronal somatic mosaics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres
Article Abstract:
Events of Endonuclease-independent long interspersed element-1 retrotransposition pathway (E[N.sub.1]) in Chinese hamster ovary having dysfunctional telomeres were studied. E[N.sub.1] retrotransposition event was found to have occurred using dysfunctional telomeres as substrates.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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