Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
Article Abstract:
Genome-wide analysis, which has combined chromatin immunoprecipitation with mouse genome tiling array profiling, is used to identify transcription factor Foxp3 binding regions and an intergenically encoded microRNA. The results have shown that distinct transcriptional sub-programs implemented by Foxp3 have established regulatory [CD4.sup.+] T-cell subset ([T.sub.R]) lineage during differentiation and its proliferative and functional competence in the periphery.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Critical genes in a critical region
Article Abstract:
The nuclear factor of activated T cells (NFAT) transcription factors are found to activate the expression of many genes involved in the immune response and the development of a variety of tissues. Two genes are implicated in the Down's syndrome critical region (DSCR), a small segment of human chromosome 21, in causing the abnormalities found in Down' syndrome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Dscam diversity is essential for neuronal wiring and self-recognition
Article Abstract:
The importance of the Down syndrome cell adhesion molecule (Dscam) gene diversity in the species, Drosophila is studied. The results show that Dscam is extremely essential for neuronal wiring and self-recognition in the circuits.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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