Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Article Abstract:

It is reported that the sonic hedgehog, a secreted hedgehog ligand, is abnormally expressed in pancreatic adenocarcinoma and its precursor lesions: pancreatic intraepithelial neoplasia. The maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis.

Ligands (Biochemistry), Hedgehogs

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Detection of preinvasive cancer cells

Article Abstract:

Issues are presented concerning the detection of preinvasive cancer cells through the use of light-scattering spectroscopy. The optical-probe technique's ability to detect early cancerous changes in epithelia is discussed.

Spectrum analysis, Spectroscopy, Cancer diagnosis

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Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

Article Abstract:

Research is presented concerning the influence of genomic integrity and senescence of human mammary epithelial cells in preventing the development of malignant lesions. Growth after senescence is discussed.

Research, Cells, Precancerous conditions, Letter to the Editor, Cell aging

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