Host factors and the pathogenesis of HIV-induced disease
Article Abstract:
Changes in the balance of human immunodeficiency virus (HIV)-inducing and HIV-suppressing host factors influence the net level of HIV viral replication and the course of the disease. The stimulation of the immune system in HIV-infected individuals by exogenous stimuli and endogenous cytokines increases viral replication. The chemoattractant cytokines RANTES, MIP-1 alpha and MIP-1 beta suppress HIV replication. Different HIV-1 strains use different chemokine co-receptors. Certain co-receptors build up a resistance for infection. Implications of the host factors are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
Article Abstract:
The location of the human immunodeficiency virus (HIV) during the course of infection was monitored in AIDS patients at various stages of the disease using polymerase chain reaction techniques. The results showed that HIV is preferentially localized at the lymphoid tissue during the early course of infection. At the intermediate stage, the virus is trapped in selected germinal centers of the follicular dendritic cells of lymph nodes. At the late stages of the disease, the virus is released from the lymph tissue to the peripheral blood mononuclear cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Viral burden and HIV disease
Article Abstract:
Recent claims of finding a cytopathic means for the progression of AIDS are faulty. The basic paradox of HIV-1 infection is that defects and cell loss occur in the presence of very few infected cells. Claims of massive infection in lymph node cells, or of high levels of virion RNA in plasma, do not account for this problem. The rebuttal view is that large intracellular reservoirs of HIV in lymphoid tissues and other factors suggest that HIV is central to pathogenesis of HIV infection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
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