A Toll-like receptor recognizes bacterial DNA
Article Abstract:
Research into the Toll-like receptor family of mediators essential in microbial recognition is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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I(kappa)B kinase-(alpha) is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
Article Abstract:
The Toll-like receptor (TLR) family has important roles in microbial recognition and dendritic cell activation. TLRs 7 and 9 can recognize nucleic acids and trigger signaling cascades that activate plasmacytoid dendritic cells to produce interferon-alpha.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Article Abstract:
The innate immune system senses viral infection by recognizing a variety of viral components, including double-stranded (ds)RNA, and triggers anti viral responses. The data obtained show that retinoic-acid-inducible protein I and melanoma-differentiation-associated gene 5 distinguish different RNA viruses and are critical for host antiviral responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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