Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
Article Abstract:
The transformation of soluble autologous proteins into insoluble amyloid fibrils as tissue deposits is linked with Alzheimer's disease, systemic amyloidosis, transmissible spongiform encephalopathy and other serious diseases. The two naturally occurring human lysozyme variants, which both cause autosomal dominant hereditary amyloidosis, are analyzed in terms of their structure, stability, fibrillogenic properties and conformational dynamics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Amyloid fibrils from muscle myoglobin
Article Abstract:
Issues are presented concerning the ability of myoglobin to convert into radically different alternative structures which closely resemble the prion and amyloid aggregates found in pathological diseases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
Article Abstract:
Research has been conducted on single-domain fragment of camelid antibody raised against wild-type human lysozyme. Results demonstrate that this fragment inhibits the aggregation of its amyloid variant.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Detrimental effects of sanctions on human altruism. Parochial altruism in humans. The efficient interaction of indirect reciprocity and costly punishment
- Abstracts: Genetic evidence for complex speciation of humans and chimpanzees. Sequencing and comparison of yeast species to identify genes and regulatory elements
- Abstracts: Structural basis for modulation and agonist specificity of HCN pacemaker channels. New player in pain
- Abstracts: Transient cross-reactive immune responses can orchestrate antigenic variation in malaria. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
- Abstracts: Erasable electrostatic lithography for quantum components. Intense equatorial flux spots on the surface of Earth's core