Interaction between a transcriptional activator and transcription factor IIB in vivo
Article Abstract:
A study was conducted to determine whether or not the activity of the glutamine-rich fushi tarazu activation domain is mediated by interactions with transcription factor II B (TFIIB). The study involved the transfection of Drosophila Schneider L2 cells with an expression plasmid encoding the 315-amino-acid Drosophila TFIIB protein whose N-terminus is fused to an 11-amino-acid epitope tag. The results showed that the activity of the activation domain is indeed mediated by ointeractions with TFIIB.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Transcription factor TFIID recruits CPSF for formation of 3' end of mRNA
Article Abstract:
Assembly of the preinitiation complex that initiates transcription by RNA polymerase II from a promoter region on DNA is induced by the binding of the TFIID transcription factor to the promoter. TFIID comprises TATA-box binding protein and TBP-associated factors. An immunopurified TFIID complex has been discovered that unexpectedly contains the cleavage-polyadenylation specificity factor, required for formation of 3' end messenger RNA. Details of the study are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Splicing-related catalysis by protein-free snRNAs
Article Abstract:
It has been established that a protein-free complex of two small nuclear RNAs (snRNAs) can bind and position a small RNA which holds the sequence of the intron branch site. This work shows the ability of protein-free spliceosomal snRNAs to catalyze a reaction connected with the first step of splicing.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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