Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
Article Abstract:
Mast cells are present at specific points of bacterial entry into the body and control the removal of bacterial cells by regulating the influx of neutrophils. Mice deficient in mast cells are unable to clear enterobacteria, unlike control mice or mice with reconstituted mast cells. The defect is due to defective neutrophil influx. Tumor-necrosis-factor (TNF) -alpha is required for the neutrophil influx, as it is released in response to incubation with bacteria. Antibodies against TNF-alpha suppress the influx.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Critical protective role of mast cells in a model of acute septic peritonitis
Article Abstract:
Mast cells and mast-cell derived anti-tumor-necrosis-factor (TNF) play an important role in initiating a protective mechanism that restricts bacterial infection to the site of the acute inflammation. Mast-cell deficient mice are susceptible to acute septic peritonitis modeled by caecum ligation and puncture (CLP). The reconstitution of the mice with cultured mast cells protects them from CLP. The injection of TNF antibodies soon after CLP blocks the protective action of mast cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic
Article Abstract:
The bacteria Escherichia coli are normal residents of the human gut but can frequently cause infections. A new study shows E. coli bound to macrophages by the bacterial lectin FimH can survive inside the cell after phagocytosis, compared to opsonized E. coli internalized through antibody. It is suggested that FimH-expressing enterobacteria relies on a glycolipid pathway that bypasses the normal phagocytic killing mechanisms.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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