Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2
Article Abstract:
A 2.0 Angstrom resolution structure of the mouse plant homeodomain (PHD) finger of tumor suppressor inhibitor of growth 2 (ING2) in complex with a histone H3 peptide trimethylated at lysine 4 (H3K4me3) is analyzed to understand its molecular mechanism. Strong binding of other ING and YNG PHD fingers suggests that the recognition of H3K4me3 histone code is a general feature of the ING/YNG proteins, providing a basis for understanding the role of the ING family of tumor suppressors in chromatin regulation and signaling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression
Article Abstract:
The crystal structure of the plant homeodomain (PHD) finger of BHC80 bound to an unmodified H3 peptide has disclosed the structural basis of the recognition of H3K4me0. Chromatin immunoprecipitation has shown that BHC80 and LSD1 has depended reciprocally on one another to associate with chromatin and has indicated that unmodified H3K4 is part of the histone code.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
Article Abstract:
The regulation of the mammalian histone methyl-transferase suppressor of variegnation 3-9 homologue 1 (SUV39H1) activity by sirtuin1 (SIRT1) during the formation of heterochromatin is explained.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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