Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion
Article Abstract:
Micro-injection of beta-noradrenergic-receptor antagonists in the bed nucleus of the stria terminalis (BNST) in rats, is shown to attenuate opiate-withdrawal-induced conditioned place aversion. It is concluded that noradrenergic inputs to the BNST from the caudal medulla have significant involvement in the aversiveness of opiate withdrawal.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Noradrenaline and attention lapses
Article Abstract:
Low alertness causes decreased performance levels such as long reaction times or failure to respond. This can be reduced by increasing the person's alertness through exposure to loud noise, for example. Noradrenaline is one of the most important form of arousal. Brain noradrenaline involves controlling attention. It has been shown that activation of noradrenergic neurons paves the way for behavioral responses. These neurons are most active during high levels of arousal.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline
Article Abstract:
It is possible to generate mice which cannot synthesize noradrenaline or adrenaline by inactivating the gene which encodes dopamine beta-hydroxylase. Such mice cannot tolerate cold because they cannot induce thermogenesis in brown adipose tissue intake. Furthermore, they have problems with peripheral vasoconstriction. Their basal metabolic rate is high, and they therefore do not gain weight, even though they consume large amounts of food. This research indicates that noradrenaline plays a key role in energy conservation in the cold. It is also important for regulation of basal metabolic rate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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