RAIDD is a new 'death' adaptor molecule
Article Abstract:
Studies on the interaction of S-labelled mammalian ICE/CED-3 family members with immobilized RIP-associated ICH-1/CED-3-homologous protein with a death domain (RAIDD) in vitro indicate that the amino-terminal domain mediates the binding of RAIDD to ICH-1 and CED-3, serving as a link to the death proteases, indicating that the prodomain may, through homophilic reactions, determine the specificity of binding of ICE/CED-3 zymogens to regulatory adaptor molecules. RAIDD functions as an adaptor molecule in recruiting the death protease ICH-1 to the TNFR-1 signalling complex.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Placing death under control
Article Abstract:
Scientists Irmler et al have identified a protein, which plays an active role in regulating the cell's life cycle. The protein is referred to as FLIP, Casper, FLAME, CASH and I-FLICE in various research programmes. It has tumour necrosis factor receptors which bring on cell death under some physiological conditions. The subject matter is one which interests several prominent research groups.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Inhibition of ICE slows ALS in mice
Article Abstract:
The progressive age-dependent diseases Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration and is universally fatal. A transgenic mouse model of ALS indicates that the interleukin-1 beta-converting enzyme (ICE) can slow down the progression of ALS, suggesting that ICE inhibitors could be of value in the treatment of ALS in humans.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Science degrees without the science. The zenith of Islamic science. Fiction informed by science
- Abstracts: Male ticks help their mates to feed. Neuron loss in APP transgenic mice
- Abstracts: Visualization of fast energy flow and solvent caging in unimolecular dynamics
- Abstracts: Regulation of neuronal diversity in the Xenopus retina by Delta signalling. Somatic linker histones cause loss of mesodermal competence in Xenopus