Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
Article Abstract:
The class IV POU-domain transcription factors, Brn-3.1 and Brn-3.2, have a specific spatio-temporal pattern of expression and regulate the final differentiation of sensorineural cells during neural development. Deletion of the Brn-3.1 gene causes loss of hair cells in the organ of Corti and sensory epithelia maculae and cristae. There is neuronal degeneration in the vestibular ganglion. Mice homozygous for deletion of the Brn-3.2 coding region have 60-70% fewer retinal ganglion cells than wild-type mice. The Brn-3.2 mutants behave normally while the Brn-3.1 mutants have defective balance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila
Article Abstract:
Examination of Drosophila mutants reveals that the synaptic current and modulation of K+ current, stimulated by a pituitary adenylyl cyclase- activating polypeptide-like neuropeptide, are controlled by coactivation of the Ras/Raf and Rutabaga-adenylyl cyclase pathways. For the G-protein- coupled neurotransmission, the Ras/Raf pathway is effective. The findings will aid the research on G-protein-coupled neurotransmission by peptides and other neuromodulators.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A neurofibromatosis-1-regulated pathway is required for learning in Drosophila
Article Abstract:
Neurofibromatosis 1 (Nf1), a tumour-suppressor gene, encodes a Ras-specific GTPase activating protein (Ras-GAP). NF1 is involved in tumour formation and has been reported as causing learning defects in humans and Nf1 knockout mice. A study shows that NF1 affects learning and short-term memory, independently of developmental effects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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